The walls of the piano nobile loggia are adorned with a continuous painted frieze that runs along its entire perimeter. The decoration features noble coats of arms belonging to commendatori, such as Cardinal Pietro Campori, Cardinal Spinola, and Cardinal Agucchi, as well as those of popes, including Innocent III of the Conti di Segni, Paul V Borghese, and Urban VIII Barberini. These are interspersed with grotesques, allegorical female figures, and landscapes—both real and imaginary—that reflect the emergence and spread of this innovative pictorial style, influenced by the presence of Flemish artists in Rome, such as the brothers Paul and Mattheus Brill. The painting style is quick and simple, suited to the loggia of a hospital and demonstrating a conscious effort to contain costs and avoid criticism. Along the loggia walls, three busts of popes—Pius VI Braschi, Pius VIII Castiglioni, and Pius IX Mastai Ferretti—are displayed alongside six 18th-century busts representing Roman emperors. The loggia also provides access to the portals of the Salone del Commendatore and the Biblioteca Lancisiana.
